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COVID-19感染与随后的甲状腺功能障碍的关联:国际基于人口的倾向性得分匹配分析
Li-An Huang1, Shih-Chang Lo1,2, Yi-Sun Yang1,2,3
1Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
Thyroid : official journal of the American Thyroid Association
|February 26, 2024
概括
COVID-19 感染显著增加了甲状腺功能障碍的风险,包括甲状腺毒性和甲状腺功能低下. 这种增加的风险在感染后持续长达12个月,影响所有年龄和性别群体.
科学领域:
- 内分泌学 在内分泌学.
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 随着COVID-19的流行,人们对其对甲状腺功能的影响产生了担忧,此前的研究得出了不确定的结果.
- 缺乏对COVID-19感染后长期甲状腺功能障碍风险的全面了解.
研究的目的:
- 调查COVID-19感染与随后患甲状腺功能障碍的风险之间的关联.
- 分析COVID-19后甲状腺毒和甲状腺功能低下症的短期和长期风险.
主要方法:
- 使用 TriNetX 国际电子健康记录数据库进行的回顾性队列研究.
- 将COVID-19患者 (病例) 与非COVID-19患者 (对照组) 的比较,通过倾向性得分匹配对人口统计学和并发症进行匹配.
- 分析甲状腺功能障碍诊断在12个月内使用危险比率和卡普兰-梅尔曲线,分层按年龄和性别.
主要成果:
- 在COVID-19患者中,甲状腺功能障碍的风险显著增加 (HR 2.07在3个月,HR ~2.01在12个月).
- 在COVID-19幸存者中观察到甲状腺毒性病 (HR 1.8-2.10) 和甲状腺功能低下症 (HR 2.04-2.08) 的风险增加.
- 在所有年龄和性别子组中都注意到风险增加,65岁以上和女性的风险更高.
结论:
- COVID-19感染与甲状腺功能障碍的持续增加风险有关,包括甲状腺毒性和甲状腺功能低下.
- 观察到的风险与患者的年龄和性别无关,尽管特定的子组可能会出现更高的敏感性.
- 需要进一步的研究来证实这些发现,并阐明潜在的机制.
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