基于人类研究,暴露于per-和多基基物质与脂质谱水平之间的关联

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Updated: Jul 2, 2025

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow

Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow

Published on: April 18, 2019

Xinru Song¹, Tingtao Ye², Dongmei Jing³

¹Department of General Surgery, Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing Medical University, Nanjing, China.

Reviews on environmental health

|February 26, 2024

概括

这项元分析发现,暴露于包括PFOA,PFOS,PFNA和PFUnDA在内的per-和多基物质 (PFAS) 与异常脂质谱有关. 减少PFAS暴露可能有助于预防脑血管疾病.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
流行病学流行病学

背景情况:

和多基基物质 (PFAS) 是广泛使用的合成化学品,对环境和健康的担忧越来越大.
流行病学研究表明,PFAS暴露与改变的脂质谱之间存在联系,但研究结果不一致.

研究的目的:

进行基于人口的流行病学研究的元分析,以澄清PFAS暴露和脂质概况水平之间的关系.
为了确定与不良脂质变化相关的特定PFAS化合物.

主要方法:

在Embase,PubMed,Ovid,Cochrane Library和Web of Science数据库中对2022年9月6日之前发表的研究进行了系统的文献搜索.
数据提取包括贝塔值,几率比率 (ORs) 和95%置信区间 (CI) 对于PFAS暴露和脂质参数之间的关联.

主要成果:

较高的低密度脂蛋白 (LDL) 水平与暴露在 perfluoroundecanoic 酸 (PFUnDA) 和 perfluorooctane 硫酸 (PFOS) 中有关.
对 perfluorooctanoic 酸 (PFOA),PFOS 和 perfluorononanoic 酸 (PFNA) 的暴露与较高的总胆固醇 (TC) 水平有显著的相关性.

结论:

已确定PFOA,PFOS,PFNA和PFUnDA是异常脂质特征的重要危险因素.
控制和减少对这些PFAS的环境暴露对于预防脑血管疾病至关重要.

关键词:

脑血管疾病脑血管疾病脂质特征脂质特征脂质特征 perfluoroalkyl 和 polyfluoroalkyl 化学物质的使用情况.

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