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Updated: Jul 2, 2025

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
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宿主编码的CTCF通过染色质循环调节人类细胞巨乳病毒的延迟时间

Ian J Groves1,2,3, Stephen M Matthews1,3, Christine M O'Connor1,2,3

  • 1Infection Biology Program, Sheikha Fatima bint Mubarak Global Center for Pathogen and Human Health Research, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.

Proceedings of the National Academy of Sciences of the United States of America
|February 26, 2024
PubMed
概括

结合CCCTC结合蛋白 (CTCF) 与人类细胞巨乳病毒 (HCMV) 结合的MIEP位点对于维持髓状细胞中的病毒延迟至关重要. 失去了CTCF结合和相关的染色质循环,促进了HCMV的重新激活.

关键词:
在CMV中使用CMV.在CTCF中,CTCF是指CTCF.细胞巨型病毒 (cytomegalovirus) 是一种病毒.表观遗传学是指表观遗传学.延迟时间 延迟时间

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