在老年人的皮肤神经酸化α-synuclein
Vincenzo Donadio1, Laura Fadda2, Alex Incensi1
1IRCCS Istituto delle Scienze Neurologiche di Bologna, UOC Clinica Neurologica, Bologna, Italy.
Journal of neuropathology and experimental neurology
|February 26, 2024
概括
化α-synuclein (p-syn) 在健康的老年人的皮肤神经中几乎不存在. 这一发现支持皮肤活检作为同核蛋白病变的特定诊断工具.
科学领域:
- 神经学 神经学
- 病理学 病理学 病理学
- 老年学是一门学科.
背景情况:
- 化α-synuclein (p-syn) 是像帕金森病这样的synucleinopathies的一个标志.
- 偶然的勒维体在老年人中很常见,但其临床意义尚不清楚.
- 小纤维神经病变可能是同核蛋白病变的早期迹象.
研究的目的:
- 为了确定p-syn在非常老,健康的受试者的皮肤神经中的发生率.
- 为了评估皮肤活检作为一种诊断工具,用于体内内核蛋白病变.
主要方法:
- 对33名老年人 (>70岁) 进行了潜在的皮肤活检.
- 试验对象接受了神经学检查.
- 在健康对照中皮肤p-syn的PubMed出版物 (2013-2023) 的文献综述.
主要成果:
- 在31名健康人群的皮肤神经中没有检测到p-syn.
- 两名非常老年人 (>98岁) 患有额外金字塔障碍的神经症状,表现出p-syn.
- 文献搜索显示,在490名健康受试者中,只有4名受试者出现了p-syn.
结论:
- 在健康个体的皮肤神经中几乎没有p-syn,包括老年人.
- 皮肤活检是一种高度特定的诊断工具,用于在体内识别同核蛋白病变.
- 皮肤神经中p-syn的存在可能表明潜在的同核蛋白病变,即使没有明显的临床症状.
更多相关视频
10:03Studying Pre-formed Fibril Induced α-Synuclein Accumulation in Primary Embryonic Mouse Midbrain Dopamine Neurons
Published on: August 16, 2020
10.6K
09:36Recombinant α- β- and γ-Synucleins Stimulate Protein Phosphatase 2A Catalytic Subunit Activity in Cell Free Assays
Published on: August 13, 2017
6.7K
相关概念视频
01:37Neural Regulation
39.4K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.4K
01:15Parkinson's Disease: Overview
546
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
546