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Updated: Jul 2, 2025

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作为EGFR/JNK-2双抑制剂的1,5-diarylpyrazoles的开发:设计,合成,分子对接和生物活性评估

Osama M Soltan1, Salah A Abdel-Aziz2, Montaser Sh Shaykoon1

  • 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut 71524, Egypt.

Bioorganic & medicinal chemistry letters
|February 26, 2024
PubMed
概括

新的pyrazole衍生物显示出作为双重抑制剂的承诺,其向表皮生长因子受体 (EGFR) 和c-Jun N-终端激酶2 (JNK-2). 这些化合物有效地抑制了癌细胞的生长,并为抗癌药物开发提供了新的策略.

关键词:
这是一种抗癌药物.迪亚里尔 (Diaryl) 皮拉醇的使用方法作为EGFR抑制剂的使用.作为JNK-2抑制剂的使用.多种激酶抑制剂 多种激酶抑制剂

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