蒂莫金对酶3的改善作用,功能和氧化应激,以及拉诱导的毒性
Zeynep Erdemli1, Mehmet Gul2, Nurcan Gokturk1
1Department of Medical Biochemistry, Medical Faculty, Inonu University, Malatya, Turkey.
Toxicon : official journal of the International Society on Toxinology
|February 26, 2024
概括
这项研究表明,食品染料塔特拉因增加氧化压力而导致脏损伤. 然而,因其强烈的抗氧化特性,蒂莫金能有效地保护人免受青素引起的毒性.
科学领域:
- 毒理学 毒理学 毒理学
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
背景情况:
- 氨酸是一种广泛使用的合成食品染料,具有潜在的不良健康影响.
- 毒性是与暴露于某些工业化学品相关的重大问题.
- 提莫金来自尼日利亚,以其抗氧化和抗炎性质而闻名.
研究的目的:
- 为了研究塔特拉对脏功能和结构的影响.
- 在大鼠模型中评估蒂莫金对塔特拉诱导的毒性产生的保护效果.
主要方法:
- 威斯塔尔白色老鼠被分为四组:对照组,塔特拉辛,蒂莫金和塔特拉辛+蒂莫金.
- 动物接受了三周的治疗,随后收集脏组织和血液样本.
- 分析了氧化应激 (MDA,SOD,TOS,OSI,GSH,GSH-Px,CAT,TAS) 和功能 (BUN,肌) 的生化标志物.
- 进行组织病理学检查,以评估结构损伤.
主要成果:
- 青素的使用导致氧化应激标志物增加,BUN和肌素水平升高,表明功能障碍.
- 组织病理学揭示了淋巴细胞和管状细胞的损伤,以及塔特拉组脏中的炎症透.
- 与tartrazine同时使用thymoquinone显著改善了生物化学参数,并改善了他的病理损伤.
- 单独用提摩诺治疗没有出现不良影响,并保持了正常的功能和结构.
结论:
- 青素诱导显著的毒性,其特点是氧化应激和功能受损.
- 蒂莫金表现出强大的抗氧化剂和保护作用,防止塔特拉诱导的脏损伤.
- 蒂莫金作为一种治疗剂,有望减轻tartrazine引起的毒性.
相关概念视频
01:24Caspases
Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside cells.
01:24Drug Toxicity: Dose-Dependent Reactions
Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...
01:25Bioactivation and Tissue Toxicity
Bioactivation is a metabolic process that transforms less reactive substances into highly reactive metabolites, initiating tissue toxicity. This transformation can lead to various toxic effects, including carcinogenesis and teratogenesis. Reactive metabolites are classified into two main types: electrophiles and free radicals.Electrophiles are electron-deficient species and are produced primarily by the enzyme cytochrome P-450 during the metabolism of compounds containing carbon, nitrogen, or...