视神经炎后脊髓的结构变化:从定量脊髓MRI的洞察力.
Jiyuan Wang1, Jing Huang1, Zheng Sun1
1Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Capital Medical University, Beijing, China.
Brain research
|February 26, 2024
概括
视神经炎 (ON) 改变了患者的脊髓扩散,由平均和辐射扩散率的增加表明. 这些变化与认知功能相关,这表明脊髓参与了ON病理.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 脊髓研究研究 脊髓研究
背景情况:
- 众所周知,视神经炎 (ON) 会影响大脑的可塑性.
- 在ON中脊髓参与仍在调查中.
研究的目的:
- 通过扩散张力成像 (DTI) 来研究ON患者的脊髓变化.
- 探索脊髓变化与ON的临床残疾之间的关联.
主要方法:
- 对101名ON患者和41名健康对照 (HC) 的回顾性研究.
- 使用磁化准备的快速获取梯度回声 (MP-RAGE) 和扩散张力成像 (DTI) 用于脊髓MRI.
- 使用扩展残疾状况表 (EDSS) 评估残疾,使用步调听力序列加法测试 (PASAT) 评估认知功能.
主要成果:
- 在ON患者和HC患者之间,脊髓横截面积 (CSA) 没有显著差异.
- 与HC患者相比,ON患者的平均扩散率 (MD) 和辐射扩散率 (RD) 增加.
- 在ON患者的轴扩散率 (AD) 降低,与PASAT得分呈正相关.
结论:
- DTI揭示了ON患者脊髓中的异常.
- 脊髓DTI提供了有关ON病理生理学和临床进展的见解.
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