在人类恶性瘤中调节免疫反应中,p53放松调节的潜在作用:开发免疫疗法的范式
Shivi Chauhan1, Shivani Jaiswal1, Vibhuti Jakhmola1
1Amity Institute of Molecular Medicine and Stem Cell Research (AIMMSCR), Amity University Uttar Pradesh, Sector-125, Noda, 201313, India.
Cancer letters
|February 26, 2024
概括
瘤抑制剂p53,往往在癌症中发生突变,可以通过抑制免疫反应,矛盾地驱动瘤生长. 了解这种双重作用是开发新免疫疗法的关键.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- TP53突变在人类癌症中很常见,影响瘤的进展.
- 新出现的证据强调TP53在瘤微环境中调节免疫系统的作用.
结论:
- 利用TP53对免疫反应的影响为新的癌症免疫治疗策略提供了潜力.
- 向p53状态可能会导致更有效的治疗人类恶性瘤.
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