休时间的久坐行为与高血压风险之间的关联:一项前性队列研究和欧洲人的两个样本的门德尔随机化分析
Zewen Li1, Wenfang Zhong2, Jian Gao3
1Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Preventive medicine
|February 26, 2024
概括
过度看电视与更高的高血压风险有因果关系. 减少屏幕时间可能有助于预防高血压,特别是在欧洲人口中.
科学领域:
- 心血管流行病学心血管流行病学
- 行为科学 行为科学
- 遗传流行病学遗传流行病学
背景情况:
- 在全球范围内,久坐不动的行为越来越普遍.
- 不同的久坐活动与高血压风险之间的具体因果关系尚不清楚.
- 了解这些关系对于公共卫生干预至关重要.
研究的目的:
- 研究特定领域的久坐行为 (看电视,使用电脑,开车) 与高血压风险之间的潜在因果关系.
- 区分各种久坐活动对高血压发展的影响.
- 为有针对性的预防策略提供证据.
主要方法:
- 在英国生物库数据 (n=261,829) 上使用考克斯回归的前性观察分析.
- 使用全基因组关联研究总结统计数据的双样本不变的门德尔随机化 (UVMR).
- 多变量门德尔随机化 (MVMR) 调整高血压风险因素.
主要成果:
- 增加电视观看 (>3小时/天) 与显著更高的高血压风险相关 (HR=1.24).
- 门德尔的随机化分析 (UVMR和MVMR) 证实了长时间看电视和高血压风险 (OR=1.45) 之间的因果关系.
- 没有发现计算机使用或驾驶行为与高血压风险有显著关联.
结论:
- 更多的电视观看时间对增加高血压风险有直接的因果关系.
- 减少看电视的时间可以作为高血压的有效预防措施.
- 特定领域的久坐行为对心血管健康有不同的影响.
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