产前暴露于多二乙烯 (PBDE) 和儿童神经发育:母乳养时间的作用
Jordyn T Wallenborn1, Carly Hyland2, Sharon K Sagiv3
1Center of Excellence for Maternal and Child Health, School of Public Health, University of California, Berkeley, CA, USA; Swiss Tropical and Public Health Institute, Department of Epidemiology and Public Health, Basel, Switzerland; University of Basel, Basel, Switzerland.
长期母乳养可能会保护儿童免受产前暴露于多二乙烯 (PBDE) 的负面影响. 在暴露于PBDE的儿童中,更长的母乳养时间与更好的执行功能有关.
科学领域:
- 环境健康 环境健康
- 神经发育毒理学 神经发育毒理学
- 儿科健康 儿科健康
背景情况:
- 产前和早期接触多二乙烯 (PBDE) 与儿童的神经发育不良结果有关.
- 作为婴儿营养的主要来源,母乳养可能会增加或减少PBDE暴露风险.
- 哺乳和产前PBDE暴露对儿童神经发育的相互作用需要进一步研究.
研究的目的:
- 为了检查母乳养是否减轻或加剧了产前PBDE暴露的神经发育影响.
- 评估母亲的PBDE水平,母乳养时间和儿童神经发育结果之间的关联.
主要方法:
- 从CHAMACOS纵向出生队列中分析了321个母婴二.
- 在母体血清样本中测量PBDE度.
- 从7岁到12岁的儿童注意力,执行功能和认知得分的长度评估,按母乳养时间分层.
主要成果:
- 较高的孕产妇PBDE度与补充母乳养时间较短 (<7个月) 的儿童的执行功能较差有关.
- 具体而言,在补充母乳养时间较短的儿童中,防腐剂误差更为严重.
- 全球执行功能得分显示,随着更长的补充母乳养时间 (≥7个月),PBDE影响较小的趋势.
结论:
- 长期母乳养 (≥7个月) 不会恶化,并且可能减轻与产前PBDE暴露相关的不良神经发育影响.
- 这些发现表明,在环境化学物质暴露的背景下,长期母乳养具有保护作用.
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