孕妇的血脂多不和脂肪酸在怀孕早期和整个怀孕期间的甲状腺功能:一项纵向研究
Ling-Jun Li1, Ruijin Lu2, Shristi Rawal3
1Global Centre for Asian Women's Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of O&G, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; NUS Bia-Echo Asia Centre for Reproductive Longevity and Equality (ACRLE), Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
怀孕早期的多不和脂肪酸 (PUFA) 对母亲的甲状腺功能有积极的影响. 像EPA和DHA这样的特定PUFAs与更好的甲状腺生物标志物和降低妊娠性甲状腺功能低下 (GHT) 风险有关.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 营养生物化学 营养生物化学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 多不和脂肪酸 (PUFA) 可能减轻甲状腺自身免疫力,改善甲状腺功能.
- 孕产妇的甲状腺功能对胎儿发育至关重要,尤其是大脑发育.
研究的目的:
- 为了确定怀孕早期的血脂PUFA是否有利于整个妊娠期间的孕产妇甲状腺功能.
- 评估PUFA和妊娠性甲状腺功能低下症 (GHT) 风险之间的关联.
主要方法:
- 分析了来自214名孕妇的长度血样本 (107名患有GDM,107名对照).
- 在各种妊娠阶段测量了11种PUFA和5种甲状腺生物标志物.
- 统计模型评估了PUFA,甲状腺生物标志物和GHT风险之间的关联.
主要成果:
- 乙酸 (EPA) 与较低的自由三氨酸 (fT3) 水平相关.
- 多可萨赫萨酸 (DHA) 与较高的自由甲状腺素 (fT4) 水平相关.
- 环氧化和多酸 (DTA) 与持续性GHT的风险降低有关.
结论:
- 特定的血脂PUFA与妊娠期间改善母亲甲状腺功能有关.
- 在怀孕早期准PUFA可能为母亲的甲状腺调节提供一种策略.
- 研究结果强调了PUFA对母亲甲状腺健康和怀孕结果的重要性.
更多相关视频
12:17The 4-vessel Sampling Approach to Integrative Studies of Human Placental Physiology In Vivo
Published on: August 2, 2017
11:44A Primary Human Trophoblast Model to Study the Effect of Inflammation Associated with Maternal Obesity on Regulation of Autophagy in the Placenta
Published on: September 27, 2017
相关概念视频
Functions of Thyroid Hormones
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
Synthesis and Regulation of Thyroid Hormones
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Gonadal and Placental Hormones
In males, testosterone is the primary gonadal androgen. It plays a central role in the maturation of male reproductive organs — the penis and testes. Additionally, testosterone is instrumental in the development of secondary sexual characteristics — a deep voice as well as facial and pubic hair...
Teratogenicity
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
