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相关概念视频

Surface Active Agents01:27

Surface Active Agents

Surfactants, named for their behavior at interfaces, positively adsorb at the interfaces of two phases, reducing interfacial tension. Their versatility as emulsifiers, detergents, and foaming agents stems from this ability. Surfactants, often termed amphiphiles, share the property of amphipathy, with molecules having both hydrophilic and hydrophobic portions. The hydrophilic part is called the head, and the hydrophobic part, including an elongated alkyl substituent, forms the tail.Surfactants...
Waterproofing and Anti-Bacterial Admixtures in Concrete01:22

Waterproofing and Anti-Bacterial Admixtures in Concrete

Concrete's susceptibility to water absorption is due to the capillary action within the pores of its hydrated cement paste. This action draws water in, creating the need for waterproofing admixtures to prevent such penetration. The efficacy of these admixtures is contingent upon the water pressure, with variations arising from different conditions such as rain, capillary rise, or hydrostatic pressure in structures intended to hold water.
Waterproofing admixtures render concrete hydrophobic,...
Biofilms01:29

Biofilms

Biofilms are complex communities of microorganisms encased in a self-produced extracellular polysaccharide matrix attached to surfaces. These microbial consortia can include single or multiple species, providing enhanced survival benefits by forming organized, multilayered structures.The formation of biofilms occurs through four key stages: attachment, colonization, development, and dispersal.During attachment, free-swimming planktonic cells adhere to a surface, often facilitated by...
Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...

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表面电荷可切换的抗积块共聚物具有细菌静止性质.

Arnab Banerjee1, Anwesha Ghosh2, Biswajit Saha1,3

  • 1Polymer Research Centre and Centre for Advanced Functional Materials, Department of Chemical Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur 741246, West Bengal, India.

Langmuir : the ACS journal of surfaces and colloids
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概括

基聚合物具有低污染性质,可以被设计成电荷可切换的囊泡. 这些Zwitter-Amphiphilic Block Copolymers (ZABCP) 显示出与pH相关的抗菌活性,对抗阳性和阴性细菌.

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科学领域:

  • 聚合物化学 聚合物化学
  • 材料科学 材料科学 材料科学
  • 生物材料是一种生物材料.

背景情况:

  • 紫聚合物是先进的材料,以其低污染特性和对生物相互作用的抗性而闻名.
  • 这些聚合物在降解细菌基质和根除生物膜方面表现有前途.
  • 为特定的生物医学应用开发具有可调节性质的材料是一个持续的挑战.

研究的目的:

  • 合成一种具有电荷切换和氧化还原敏感性质的新型两块共聚合物 (ZABCP).
  • 研究ZABCP在囊泡中的自我组装及其pH响应的表面电荷切换.
  • 评估ZABCP囊泡作为对抗细菌病原体的细菌静止剂的潜力.

主要方法:

  • 模块化合成一种两块共聚合物 (ZABCP),其中包括一个可切换电荷的聚聚烯片段和一个对氧化还原敏感的二硫化物标记的聚甲烯酸块.
  • 描述 ZABCP 囊泡形成,水力动力直径 (180 ± 20 nm) 和依赖于 pH 的表面电荷切换 (zeta 电位从 -23 到 +36 mV).
  • 评估蛋白质结合相互作用,并通过形态变化和膜破坏对细菌素和大肠杆菌的细菌静止活性的评估.

主要成果:

  • 在响应pH值变化的情况下,ZABCP成功地形成了具有可调的表面电荷的囊泡.
  • 随着囊泡表面电荷从中性转移到阴离子或阴离子,蛋白质结合亲和力增加.
  • 阴离子ZABCP囊泡表现出显著的细菌静止作用,导致格拉姆阳性和格拉姆阴性细菌的形态变化和膜破坏.

结论:

  • 合成的ZABCP是一种多用途的zwitterionic聚合物,能够形成可切换电荷的囊泡.
  • 控制pH的表面电荷切换增强了与生物实体的相互作用,包括细菌膜.
  • ZABCP囊泡为开发有效的,低污染的抗菌材料提供了一个有希望的平台.