移植后的塔克罗利斯诱导的胆固醇性肝毒性:一个病例报告
Fatemeh Pourrezagholi1, Hossein Amini2, Omid Moradi3
1Chronic Kidney Disease Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Journal of medical case reports
|February 26, 2024
概括
在移植患者中,塔克罗利马斯可以导致肝损伤 (肝毒性). 切换到环素解决了塔克罗利斯诱导的高白血症和改善了肝酶.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 肝病学 肝病学是一种肝病学.
- 移植 移植 移植 移植
背景情况:
- 接受移植的人通常需要免疫抑制疗法.
- 塔克罗利斯是一种常用的移植后免疫抑制剂.
- 药物诱导的肝损伤是免疫抑制药物的潜在并发症.
研究的目的:
- 报告与塔克罗利斯相关的肝毒性病例.
- 突出移植患者药物诱导肝损伤的诊断挑战和管理.
主要方法:
- 一个56岁的男性脏移植接受者的病例报告.
- 黄的临床表现,虚弱和昏迷.
- 实验室发现包括高胆血和肝酶升高.
- 排除肝毒性的传染性原因.
- 药物诱导的肝损伤的诊断.
主要成果:
- 患者在移植和塔克罗利斯开始治疗后两周内出现了黄和升高的肝酶.
- 排除了肝损伤的传染性病因.
- 将免疫抑制从塔克罗利斯转换为环素导致胆红素和肝酶的减少.
- 患者在肝炎症状消失后出院.
结论:
- 塔克罗利被确定为可能导致高白血症和肝毒性的原因.
- 停止使用塔克罗利斯并替换为环素有效地控制了肝损伤.
- 这一案例强调了监测TACROLIMUS治疗移植患者的肝功能的重要性.
更多相关视频
相关概念视频
Pulmonary Tuberculosis I
1.7K
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.7K
Kidney Transplant I: Introduction
827
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
827
Kidney Transplant II: Surgical Procedure
926
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
926
Kidney Transplant III: Nursing Management
631
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
631


