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Updated: Jul 2, 2025

Phenotypic and Functional Analysis of Activated Regulatory T Cells Isolated from Chronic Lymphocytic Choriomeningitis Virus-infected Mice
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1型干扰素和Foxo1降低调节在老年T细胞衰竭中起着关键作用

Aurélie Durand1, Nelly Bonilla1, Théo Level1

  • 1Université Paris-Cité, Institut Cochin, Centre National de la Recherche Scientifique (CNRS) UMR8104, Institut National de la Santé et de la Recherche Médicale (INSERM) U1016, 75014, Paris, France.

Nature communications
|February 26, 2024
PubMed
概括

衰老会降低小鼠T细胞中的Foxo1水平,破坏免疫平衡并促进T细胞疲劳. 1型干扰素驱动这种衰退,导致与年龄相关的T细胞功能障碍.

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相关概念视频

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
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