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Updated: Jul 2, 2025

ACT1-CUP1 Assays Determine the Substrate-Specific Sensitivities of Spliceosomal Mutants in Budding Yeast
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SPOP点突变调节基质偏好并影响其功能

Yanran Deng1,2, Wenhao Ding3, Kaize Ma3

  • 1Jiangsu Key laboratory of Drug Screening, China Pharmaceutical University, 210009, Nanjing, China.

Cell death & disease
|February 26, 2024
PubMed
概括

该研究确定IRF2BP2是SPOP的基质,SPOP是一种参与癌症的蛋白质. 矛盾的是,SPOP中的突变可以通过改变其与IRF2BP2的相互作用来促进癌症.

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