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Updated: Jul 2, 2025

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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帕诺比诺斯塔特的药理动力学:代谢稳定的物种间差异

Wenqiu Zhang1, Ju-Hee Oh2, Wenjuan Zhang2

  • 1Departments of Pharmaceutics, Brain Barriers Research Center (Wenq. Zhang, J.-H.O., Wenj. Zhang, W.F.E.) and Medicinal Chemistry (C.C.A.), University of Minnesota, Minneapolis, Minnesota; and Department of Neurologic Surgery, UMass Chan Medical School, Worcester, Massachusetts (R.W.S.) elmqu011@umn.edu zhan4937@umn.edu.

The Journal of pharmacology and experimental therapeutics
|February 26, 2024
PubMed
概括

胰岛素胺,一种基因素脱乙酶抑制剂,在小鼠菌株中显示出不同的体外稳定性,但在体内药理动力学和中枢神经系统输送方面相似,突出了预测药物行为的挑战.

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