对2019年新冠病毒病患者年龄特定预测死亡率的分析
1Department of Emergency Medicine, University of Health Sciences, Haseki Training and Research Hospital, Istanbul, Turkey.
Nigerian journal of clinical practice
|February 26, 2024
概括
住院COVID-19患者的死亡率预测因年龄而异. 高龄,慢性功能衰竭和乳酸脱酶升高在老年人中是关键因素,而慢性阻塞性肺病和高血小板计数在年轻患者中是显著的.
科学领域:
- 内部医学 内部医学
- 传染性疾病 传染性疾病
- 临界护理医学 临界护理医学
背景情况:
- 冠状病毒疾病2019 (COVID-19) 肺炎带来了显著的死亡风险.
- 确定死亡率预测因素对于管理住院患者至关重要.
研究的目的:
- 调查住院COVID-19肺炎患者死亡率的人口,临床和实验室预测因素.
- 为了比较不同年龄组 (≥65岁和<65岁) 之间的预测指标.
主要方法:
- 对651名入院COVID-19的土耳其成年人进行了回顾性,单中心研究.
- 收集的数据包括人口,临床和实验室参数.
- 用多变量逻辑回归分析来确定死亡率的独立预测因素.
主要成果:
- 总体死亡率为10.6%,男性的死亡率更高.
- 所有年龄段死亡率的独立预测因素包括晚年,慢性功能衰竭 (CRF),延长激活的部分血栓形成时间,高血清中性粒细胞和血小板数量,高C-反应蛋白与白蛋白 (CRP/白蛋白) 的比率,以及高白蛋白,乳酸脱酶 (LDH) 和高灵敏性热素I (TnI-hs).
结论:
- 在65岁以下的患者中,预测因素包括慢性阻塞性肺病 (COPD),高血小板计数,高CRP/白蛋白比率,白蛋白升高,TnI-hs和D-二次体.
- 在65岁以上的患者中,预测因素包括晚年,冠状动脉疾病 (CAD),CRF和血清CRP和LDH水平升高.
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