格雷林降低了对负面反的敏感性,并增加了与预测错误相关的人类尾巴活动,这是一个随机对照试验
Michal Pietrzak1,2,3, Adam Yngve1,3, J Paul Hamilton1,3,4
1Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, 58183, Sweden.
概括
胃激素格林降低了对惩罚的敏感性,并增加了大脑中奖励预测错误信号. 这表明格林素影响的奖励处理不仅仅是饥饿,可能会影响冒险行为.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 行为科学 行为科学
背景情况:
- 格雷林是一种来自胃的激素,以其在食和生存中的作用而闻名.
- 新出现的证据表明,格林在压力,神经精神疾病和物质使用障碍中参与.
- 奖励处理机制被假设为中介格林对复杂行为的影响.
研究的目的:
- 调查格林对健康志愿者奖励和惩罚敏感性的影响.
- 为了检查格林对大脑活动的影响,与学习任务期间的奖励预测错误有关.
- 探索格林在奖励处理中的作用,超出其已知的食欲调节功能的范围.
主要方法:
- 使用了对象内部,双盲,安慰剂控制的设计.
- 静脉注射格林注给了30名健康志愿者.
- 在功能性脑成像 (fMRI) 期间进行了带有金钱奖励的逆向学习任务.
- 计算建模用于导出行为参数.
主要成果:
- 与安慰剂相比,格雷林显著降低了对惩罚的敏感性 (p=0.021).
- 对奖励的敏感性在 ghrelin 给药后保持不变 (p=0.43).
- 格林增加了背上条纹体 (p≤0.044) 中预测错误相关的活动 (p≤0.044).
结论:
- 格林调节奖励处理,影响对负面结果的敏感性.
- 背上条纹体活动增加表明,在格林下,奖励预测错误的处理得到了增强.
- 这些发现支持格林在奖励处理中的更广泛作用,可能与冒险和冲动性有关.
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