同声化协为高效的绿色纳米封装植物通过合性非生物毒性固体脂质纳米颗粒
Zolfaghar Mahdlou1, Rahebeh Amiri Dehkharghani2, Ali Niazi3
1Department of Chemistry, Central Tehran Branch, Islamic Azad University, P.O. Box 1465613111, Tehran, Iran.
Scientific reports
|February 26, 2024
概括
使用体系统 (SLN) 纳米封装植物可以提高它们的稳定性和分散性,从而降低胆固醇. 这种绿色协方法可以产生稳定的,具有高封装效率的亚-100nm植物体纳米粒子.
科学领域:
- 生物技术是生物技术.
- 材料科学 材料科学 材料科学
- 营养保健品 营养保健品
背景情况:
- 植物醇是有效的LDL胆固醇降低剂.
- 低分散性和不稳定性限制了植物的应用.
- 纳米封装提供了一种解决方案,以提高植物的疗效.
研究的目的:
- 使用合体系统 (SLN) 开发稳定的植物纳米封装.
- 为了优化纳米封装过程,以改善颗粒大小和载荷能力.
- 评估植物体纳米颗粒的稳定性,抗微生物活性和释放行为.
主要方法:
- 从亚麻油中提取的植物被纳米封装使用基于脂质的合体系统的共声化化.
- 鉴定包括FTIR,UV-Vis,SEM,DLS和GC分析.
- 贝恩肯设计 (BBD) 优化了颗粒大小和封装效率 (EE%).
主要成果:
- 100nm以下的SLNs获得了高植物含量 (EE%为85.46%) 和正泽塔潜力.
- 纳米粒子表现出抗菌活性和受控释放行为.
- 六个月的稳定性研究证实了纳米封装植物的增强稳定性.
结论:
- 绿色协是一种有效的生产稳定的植物体纳米颗粒的方法.
- 纳米封装显著改善了植物的分散性和稳定性.
- 这种方法为传统的植物输送方法提供了更好的替代方案.
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