识别了调节巨细胞mTOR信号和心血管风险的白介导值效应
Xiangyu Zhang1,2, Divya Kapoor3,4, Se-Jin Jeong3
1Department of Medicine and Vascular Medicine Institute, University of Pittsburgh School of Medicine and UPMC, Pittsburgh, PA, USA.
Nature metabolism
|February 26, 2024
概括
高蛋白饮食可以增加心血管风险. 过度摄入蛋白质,特别是每餐超过25g,会激活巨细胞中的mTOR信号,导致动脉样硬化症的发展,特别是在男性中.
科学领域:
- 心血管科学 心血管科学
- 代谢信号传递 代谢信号传递
- 营养免疫学 营养免疫学
背景情况:
- 高蛋白质摄入量在西方饮食中很普遍,并且经常被鼓励健康.
- 氨基酸介导的猛素 (mTOR) 在巨细胞中传递信号的哺乳动物点与心血管疾病的发病有关.
- 食蛋白成分在巨细胞激活和心血管风险中的特定作用需要阐明.
研究的目的:
- 为了确定负责巨细胞mTOR激活的关键氨基酸.
- 为了确定饮食蛋白质摄入的门,触发mTOR信号和不利的心血管影响.
- 调查过多的蛋白质和白素摄入量对动脉样硬化发展的影响.
主要方法:
- 临床研究 (NCT03946774,NCT03994367) 涉及人类分级摄入蛋白质和血氨基酸分析.
- 人类单细胞/巨细胞实验以评估mTOR信号激活.
- 在小鼠模型中开发和测试修改饮食,以评估蛋白质和白对动脉样硬化的影响.
主要成果:
- 氨酸被确定为巨细胞中mTOR信号传递的主要激活剂.
- 观察到一个值效应:每餐蛋白质摄入量超过大约25g,诱导了mTOR激活和单细胞/巨细胞的功能变化.
- 过多的食蛋白质 (超过22%的能量需求) 在雄性小鼠中促进了动脉样硬化.
结论:
- 过多的饮食蛋白质摄入,由白驱动,机械地导致心血管风险.
- 每餐摄入蛋白质的特定门对于激活巨细胞mTOR信号来说至关重要.
- 这些发现提供了高蛋白饮食和动脉样硬化增加之间的机制联系,特别是在男性中.
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