高盐摄入量是否通过皮质醇的产生诱导肥胖? 一个新的工作假设和试点研究
Anthony Nowell1, Susan J Torres1, Sarah J Hall1
1Institute for Physical Activity and Nutrition, Deakin University, Geelong, VIC, Australia.
European journal of nutrition
|February 27, 2024
概括
高盐摄入量可能会通过增加皮质醇增加肥胖风险. 一项研究显示,在高盐饮食后,皮质醇和ACTH反应急剧升高,这表明盐,皮质醇和肥胖之间存在联系.
科学领域:
- 内分泌学 在内分泌学.
- 人类营养人类营养
- 代谢研究研究 代谢研究
背景情况:
- 越来越多的证据将高盐摄入量与肥胖联系在一起.
- 基本的机制仍然在很大程度上是未知的.
- 一个新的假设表明,高盐摄入量刺激皮质醇的产生,导致肥胖.
研究的目的:
- 为了研究一次高盐饮食后的急性皮质醇反应.
- 探索盐在皮质醇生产和肥胖中的潜在作用.
主要方法:
- 八名参与者 (50%是女性,平均年龄为30.5岁) 参加了一项随机交叉研究.
- 参与者食用高盐 (3.82克) 和低盐 (0.02克) 的食物.
- 测量了尿液和唾液中的皮质醇和血ACTH水平.
主要成果:
- 尿皮质醇 (26.3%),唾液皮质醇 (9.4%) 和血ACTH (4.1%) 的显著增加在食用第二次高盐餐时被观察到.
- 这些荷尔蒙水平随后显著下降.
- 没有观察到有意义的荷尔蒙变化,当高盐的饭菜是第一次消耗.
结论:
- 这些发现部分支持了高盐摄入量会影响皮质醇产生的假设.
- 需要进一步的研究才能充分理解盐-皮质醇-肥胖的联系.
- 这项研究突出了通过荷尔蒙机制将食盐与肥胖联系起来的潜在途径.
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