各种重金属暴露对非糖尿病人群胰岛素耐药性的影响:从机器学习建模角度进行解释性分析
Jun Liu1, Xingyu Li2, Peng Zhu3
1Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, 74 Linjiang Road, Yuzhong District, Chongqing, 400010, China.
Biological trace element research
|February 27, 2024
概括
暴露于重金属,包括尿路和,与胰岛素抵抗 (IR) 有关. 机器学习模型将这些金属确定为关键预测指标,建议针对IR管理进行有针对性的控制.
科学领域:
- 环境健康 环境健康
- 代谢障碍 代谢障碍 代谢障碍
- 计算生物学 计算生物学
背景情况:
- 胰岛素抵抗 (IR) 是一个日益严重的健康问题,与环境因素有关.
- 越来越多的重金属暴露被认为是IR发展的重要贡献者.
研究的目的:
- 开发和验证可解释的机器学习 (ML) 模型,以基于重金属暴露水平来预测IR.
- 确定特定的重金属是非糖尿病人群中IR的主要影响者.
主要方法:
- 利用了来自NHANES (2003-2020) 的4354名参与者的数据.
- 训练并评估了12个ML算法,其中随机森林 (RF) 显示出最佳性能 (80.14%准确率,0.856AUC).
- 采用可解释的方法 (转换重要性,PDP,SHAP) 来理解模型预测.
主要成果:
- 确定了尿中的 (Ba),尿中的 (Mo),血液中的 (Pb) 和血液中的 (Cd) 作为IR的关键预测因素.
- 尿中的Ba和Mo显示IR风险趋势上升,而血液中的Pb和Cd显示下降趋势.
- 控制尿液中的Ba水平对于IR管理尤为重要.
结论:
- 可解释的ML模型有效地根据重金属暴露预测了IR风险.
- 特定的重金属 (Ba,Mo,Pb,Cd) 在IR发展中发挥着重要作用.
- 结果支持通过重金属水平监测和控制来个性化IR管理策略.
更多相关视频
相关概念视频
Diabetes Mellitus: Type 2 and Gestational
2.4K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.4K
Carbohydrate Metabolism
11.1K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
11.1K
Diabetes Mellitus: Overview and Type I Subtype
2.6K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.6K
Insulin: The Receptor and Signaling Pathways
1.2K
Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
1.2K
Diabetes: Symptoms, Diagnosis, and Complications
539
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
539
Pathophysiology of Diabetes
935
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
935


