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在多发性硬化症中,可通过结构性MRI估计胆管体体积,避免对比注射
Valentina Visani1, Francesca B Pizzini2, Valerio Natale3
1Department of Information Engineering, University of Padova, Padova, Italy.
European radiology experimental
|February 27, 2024
概括
非对比度T1加权 (T1w) MRI序列可以准确地估计胆管 (ChP) 体积,作为对比度增强的T1w序列的可行替代品. 液体减弱反转恢复 (FLAIR) 序列高估了CHP体积,使T1w序列在多发性硬化症研究中更适合细分.
科学领域:
- 神经成像是一种神经成像.
- 放射学 放射学是指放射学
- 医学图像分析 医学图像分析
背景情况:
- 冠状动脉 (ChP) 是大脑心室内的一个关键结构.
- 精确的CHP细分对于理解其在多发性硬化症 (MS) 等神经疾病中的作用很重要.
- 与对比度增强的T1加权 (CE-T1w) 序列通常被认为是ChP细分的参考标准.
研究的目的:
- 通过使用非对比增强 (非CE) T1加权 (T1w) 和流体减弱反转恢复 (FLAIR) 序列与参考标准CE-T1w序列比较手动状交叉体细分的准确性和可靠性.
- 评估非CE T1w序列作为CE-T1w序列替代品的适用性,以估计多发性硬化症患者的CHP体积.
- 为了评估与CE-T1w序列相比,FLAIR序列对CHP体积的高估.
主要方法:
- 在61名多发性硬化症患者的T1w,FLAIR和CE-T1wMRI序列上,手动细分胆膜 (ChP).
- 评估者之间的变异性是使用类内相关系数 (ICC) 进行评估的.
- 计算了信号与噪声比率 (SNR),对比与噪声比率 (CNR) 和子相似系数 (DSC). 在对MNI152空间进行非线性校正后,分析了空间错误分布.
主要成果:
- 在所有序列中都观察到高的分级间可重现性 (ICC:T1w=0.93,FLAIR=0.93,CE-T1w=0.99).
- 与T1w和FLAIR序列相比,CE-T1w序列显示出更高的SNR和CNR.
- 与CE-T1w (2.984 ± 0.506 mL) (p < 0.001) 相比,FLAIR序列显著高估了CHP体积 (3.787 ± 0.679 mL),误差为28.02 ± 19.02%.
- 非CE T1w 序列提供了可接受的误差 (3.52 ± 12.61%) 并显示与CE-T1w (DSC=0.67 ± 0.05) 有很好的一致性,这表明T1w 是CE-T1w的替代品.
- 空间错误分布是异质的,特别是在和海马附近.
结论:
- 非对比的T1w序列可以作为CE-T1w序列的可靠替代品,用于在多发性硬化症患者中估计状体体积.
- FLAIR序列倾向于高估CHP体积,不太适合准确的体积评估.
- 这些发现支持自动细分工具的开发,并促进研究CHP体积在多发性硬化症中的作用的纵向研究.
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