耐药粉摄入量通过重塑肠道微生物群来促进人类的体重减轻
Huating Li1,2,3, Lei Zhang4,5, Jun Li6,7
1Shanghai Key Laboratory of Diabetes Mellitus, Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. huarting99@sjtu.edu.cn.
耐性粉 (RS) 补充剂有助于减肥,并改善超重个体的胰岛素抵抗. 这些好处与肠道微生物群的变化有关,特别是Bifidobacterium adolescentis,它可以防止肥胖.
科学领域:
- 微生物学 微生物学
- 代谢健康 代谢健康
- 营养科学 营养科学
背景情况:
- 肠道微生物群的食纤维调节对代谢障碍有希望.
- 耐性粉 (RS) 是一种具有潜在健康益处的食纤维.
研究的目的:
- 研究耐性粉 (RS) 补充对与肥胖相关的结果的影响.
- 探索肠道微生物群在调解RS的影响中的作用.
主要方法:
- 随机的安慰剂受控交叉试验与37名超重/肥胖参与者.
- 分析肠道微生物群的组成及其与减肥和胰岛素抵抗的关联.
- 用于评估Bifidobacterium adolescentis对饮食引起的肥胖的保护作用的小鼠模型.
主要成果:
- 8周的RS补充剂导致显著的体重减轻 (平均减轻2.8公斤) 和改善胰岛素抵抗.
- 补充RS改变了肠道微生物群的组成,Bifidobacterium adolescentis显示出与减轻肥胖症的强烈关联.
- Bifidobacterium adolescentis补充剂保护了雄性小鼠免受饮食诱导的肥胖.
- 机制包括改变胆酸概况,通过肠道屏障恢复减少炎症,并抑制脂质吸收.
结论:
- 耐性粉 (RS) 有助于减肥,并改善过重的人的代谢健康.
- 肠道微生物群,特别是Bifidobacterium adolescentis,在调解RS的有益作用方面发挥着至关重要的作用.
- RS可能提供一个可行的饮食策略来管理肥胖和相关的代谢障碍.
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