解释变化以及对竞争风险的必要性和充分性的程度和生存数据
Andreas Gleiss1, Michael Gnant2, Michael Schemper1
1Center for Medical Data Science, Institute of Clinical Biometrics, Medical University of Vienna, Vienna, Austria.
Biometrical journal. Biometrische Zeitschrift
|February 27, 2024
概括
这项研究扩展了Shemper-Henderson测量,以分析与竞争事件 (CE) 相关的生存数据. 增强的措施为复杂的生存结果的解释变异提供了新的见解.
科学领域:
- 生物统计学 生物统计学
- 生存分析的分析.
- 流行病学 流行病学
背景情况:
- 施佩尔-亨德森测量量生存结果的解释变化.
- 现有的措施不能充分考虑竞争事件,这是许多健康研究中常见的.
研究的目的:
- 将解释变化的Shemper-Henderson测量扩展到与竞争事件相匹配的生存数据.
- 提供人口层面的估计,并探索分解为必要性和充分性.
主要方法:
- 利用无条件和有条件的累积发病率函数,从Fine和Gray模型中得出.
- 解释变化的扩展的乘法分解成必要性和充分性.
主要成果:
- 扩展的措施准确地适应竞争事件,在没有竞争事件的情况下,减少到原始措施.
- 经验性属性通过人口层面的分析和模拟来探索.
- 在乳腺癌数据集中展示了高比例的竞争事件的证明实用性.
结论:
- 扩展的Shemper-Henderson测量提供了一个可靠的方法来评估在存在竞争性风险时的解释变化.
- 为生物统计和流行病学研究提供了有价值的工具,促进更好地理解复杂的生存数据.
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