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吸烟和饮酒与良性上腺瘤之间的关联:孟德尔的随机化研究
Kun Peng1, Qingyuan Liu1, Ning Wang1
1Department of Urology, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, 450003, China.
Endocrine
|February 27, 2024
概括
吸烟,特别是每天一包香烟和每年一包香烟,因果性地增加了良性上腺瘤的风险. 然而,酒精消费与这些瘤没有因果关系.
科学领域:
- 内分泌学 在内分泌学.
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 增加上腺瘤的检测率需要了解风险因素.
- 吸烟,酒精和良性上腺瘤之间的关系尚不清楚.
研究的目的:
- 使用孟德尔随机化 (MR) 调查吸烟,饮酒和良性上腺瘤之间的因果关系.
主要方法:
- 利用了大规模的全基因组关联研究 (GWAS) 关于吸烟和饮酒的数据.
- 采用孟德尔随机化 (MR) 与反向差异加权 (IVW),MR-Egger和加权中位数估计 (WME).
- 进行敏感性分析以确保调查结果的可靠性.
主要成果:
- 吸烟,特别是每年一包和每天一包香烟,表明对良性上腺瘤的因果风险 (OR=2.853,P=0.004;OR=1.543,P=0.004).
- 在一般吸烟状况,饮酒状况或各种饮酒量和良性上腺瘤之间没有发现因果关系.
- 特定的单核酸多态 (SNP) rs8042849和rs8034191被确定为观察到的因果效应的关键驱动因素.
结论:
- 门德尔随机分析表明,吸烟习惯和良性上腺瘤之间存在因果关系.
- 饮酒似乎对良性上腺瘤的发展没有因果关系.
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