在连续脏替代疗法期间的抗菌剂量建议:不同的数据库,不同的剂量
Aysel Pehlivanli1,2, Tuğba Yanik Yalçin3, Fatma İrem Yeşiler4
1Pharmacology Department, Faculty of Pharmacy, Başkent University.
Journal of chemotherapy (Florence, Italy)
|February 27, 2024
概括
准确的抗微生物剂量对于患有急性损伤,需要持续置换疗法 (CRRT) 的重症患者至关重要. 微米德克斯数据库与CRRT药物剂量调整的黄金标准最接近.
科学领域:
- 药理学 药理学是指药理学的学科.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 关键护理医学 关键护理医学
背景情况:
- 有效的抗微生物治疗对于急性损伤 (AKI) 严重患者至关重要.
- 连续脏替代疗法 (CRRT) 期间的药物清除复杂化了抗菌剂的剂量.
- 准确的剂量调整是必要的,以确保治疗疗效,并避免在CRRT的AKI患者中出现毒性.
研究的目的:
- 评估和比较用于调整CRRT患者抗微生物药物剂量的常用数据库的准确性.
- 确定最可靠的数据库,以指导CRRT特定的抗微生物剂量与既定的黄金标准相比.
主要方法:
- 通过CRRT清除的抗微生物药物的剂量建议从各种数据库中提取.
- 一本公认的药物治疗参考书被指定为比较的黄金标准.
- 计算了Micromedex,UpToDate和Sanford数据库与黄金标准的对应率.
主要成果:
- 在评估的数据库中观察到关于CRRT抗菌剂量建议的显著差异.
- 微米德克斯表现出与黄金标准的最高相似性,一致率为45%.
- UpToDate和Sanford的一致率分别较低,分别为35%和30%.
- 专家小组会议召开,讨论差异,并就剂量建议达成共识.
结论:
- 目前的数据库在为CRRT患者提供准确的抗菌剂剂量调整方面表现出变化.
- 在CRRT抗菌剂剂量评估中,Micromedex数据库似乎是最可靠的资源.
- 建议在专家之间进一步建立共识,以完善CRRT的AKI患者的抗菌剂剂量指南.
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