系统性免疫炎症指数和胃癌预后:系统性审查和元分析
1Department of Gastrointestinal Hernia, Huzhou Central Hospital, The Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, Zhejiang 313000, P.R. China.
Experimental and therapeutic medicine
|February 27, 2024
概括
高的全身免疫炎症指数 (SII) 水平预测胃癌 (GC) 患者的生存率不佳. 这一元分析证实SII是GC中总生存 (OS) 和无复发生存 (RFS) 的重要预后生物标志物.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物统计学 生物统计学
背景情况:
- 胃癌 (GC) 仍然是全球癌症死亡的主要原因.
- 确定可靠的预后生物标志物对于改善患者的治疗结果至关重要.
- 系统性免疫炎症指数 (SII) 是系统性炎症和免疫反应的潜在指标.
研究的目的:
- 进行一项元分析,汇集系统性免疫炎症指数 (SII) 与胃癌 (GC) 患者的生存结果之间的关联数据.
- 评估SII对GC总生存 (OS) 和无复发生存 (RFS) 的预后价值.
- 评估SII在不同研究特征中的预后作用的一致性.
主要方法:
- 在PubMed,EMBASE和Scopus数据库中对观察性研究进行系统的文献搜索.
- 使用随机效应模型组合效应大小的元分析.
- 用95%的置信区间 (CI) 计算出危险比率 (HR),以量化SII与生存之间的关联.
主要成果:
- 分析包括30项研究,随访期为15.5至65.6个月.
- 治疗前高的SII水平与整体存活率差 (HR,1.53;95% CI,1.34-1.75) 有显著的关联.
- 治疗前高的SII水平也与不良的无复发生存率 (HR,1.41;95% CI,1.17-1.70) 有显著的关联.
结论:
- 治疗前系统性免疫炎症指数 (SII) 是胃癌 (GC) 患者整体存活率低下和无复发存活率的重要预测指标.
- 对SII的预后值在各种治疗策略,样本大小和SII截止值中是一致的.
- 升高的SII水平表明诊断为胃癌的患者的预后较差.
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