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评估血清血管内皮生长因子和糖尿病外围神经病变中的皮菌素的诊断潜力
Palani Selvam Mohanraj1, Arani Das2, Aniruddha Sen1
1Biochemistry, All India Institute of Medical Sciences, Gorakhpur, Gorakhpur, IND.
Cureus
|February 27, 2024
概括
血管内皮生长因子 (VEGF) 可能有助于诊断2型糖尿病 (T2DM) 患者的糖尿病外围神经病变 (DPN). 升高的VEGF水平与DPN的严重程度相关,而不是adiponectin
科学领域:
- 内分泌学 在内分泌学.
- 神经学 神经学
- 生物化学 生物化学
背景情况:
- 糖尿病外围神经病变 (DPN) 是2型糖尿病 (T2DM) 的重要并发症.
- 了解DPN的分子机制对于改善诊断和管理至关重要.
- 这项研究主要集中在印度东部的北方邦.
研究的目的:
- 调查血管内皮生长因子 (VEGF) 和阿迪波涅丁在T2DM患者中DPN中的作用.
- 评估VEGF和阿迪波内克丁对DPN的诊断潜力.
- 评估这些生物标志物与神经病变严重程度的相关性.
主要方法:
- 在86名35-65岁的T2DM患者 (43名有DPN,43名没有) 的横截面研究中.
- 使用神经病症症状评分 (NSS),糖尿病神经病症检查 (DNE) 评分和神经传导研究进行神经病症评估.
- 测量VEGF和adiponectin血清水平,与临床和电生理学参数相关联.
主要成果:
- 与对照人群相比,DPN患者的VEGF水平显著更高.
- VEGF与运动神经振幅有负相关性,与NSS和DNE得分有正相关性.
- VEGF表现出强大的诊断能力 (AUC=0.807),是DPN的唯一显著预测因子.
结论:
- 作为DPN诊断和T2DM严重程度评估的生物标志物,VEGF显示出有前途.
- 在这个队列中,阿迪波涅丁水平与DPN没有显著的关联.
- NSS和DNE分数是评估T2DM神经病变的验证工具.
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