患有创伤后应激障碍的儿童和青少年的α-2激动剂:系统性审查
Amit Jagtiani1, Raghu Gandhi2, Akshat Banga3
1Psychiatry, Burrell Behavioral Health, Springfield, USA.
Cureus
|February 27, 2024
概括
像克洛尼丁这样的α-2 (α2) 激动剂在减少儿科创伤后应激障碍 (PTSD) 症状,特别是睡眠障碍和过度兴奋方面表现出初步有效性. 需要进一步的研究来证实有效性和安全性.
科学领域:
- 儿科精神病学 儿科精神病学
- 儿童和青少年心理健康
- 药理学研究 药理学研究
背景情况:
- 创伤性压力暴露在儿童中很普遍,往往导致创伤后应激障碍 (PTSD).
- 儿童PTSD的精神药物治疗方法有限,一些证据支持α-2 (α2) 激动剂.
- 阿尔法-2 (α2) 激动剂,包括克洛尼丁和关法辛,正在研究它们在管理PTSD症状方面的潜力.
研究的目的:
- 系统地审查和评估α-2 (α2) 激动剂在治疗儿童和青少年PTSD症状中的有效性.
- 识别和分析关于克洛尼丁和关法辛治疗儿科PTSD的已发表研究.
主要方法:
- 在主要数据库 (PubMed,MEDLINE,EMBASE,Cochrane,PsycINFO) 进行系统的文献搜索.
- 包括评估小儿PTSD症状的克洛尼丁或关法辛的研究.
- 遵守PRISMA指南和Prospero注册 (ID:CRD42021273692) 的要求.
主要成果:
- 确定了10项关于克洛尼丁或关法辛治疗儿科PTSD的研究.
- 克隆丁在减少整体PTSD症状方面表现出可变的有效性.
- 这两种药物都在缓解梦,过度兴奋,侵略性,睡眠障碍和特定的PTSD症状集群方面表现出有效性.
结论:
- 对于儿科PTSD症状的α-2 (α2) 激动剂的有效性目前是初步的.
- 没有发现随机,双盲,安慰剂对照试验,突出显示高质量的证据存在差距.
- 未来的安慰剂对照试验对于确定α-2 (α2) 激动剂在该人群中的有效性和安全性至关重要.
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