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从含有细胞外囊泡的脂质和杉类同质体中纳米混合体的表征

Vesna Spasovski^1,2, Anna Romolo^1,3, Urška Zagorc⁴

¹University of Ljubljana, Faculty of Health Sciences, Laboratory of Clinical Biophysics, Ljubljana, Slovenia.

International journal of nanomedicine

|February 27, 2024

概括

研究人员从松树针中开发了新的纳米混合体 (NSH),为生产生物活性脂质纳米纤维提供了可扩展和具有成本效益的方法. 这些NSH代表了天然产品交付系统的重大进步.

科学领域:

生物技术是生物技术.
材料科学材料科学材料科学
植物化学植物化学

背景情况:

脂质纳米纤维对于药物输送至关重要.
松树针均酸含有有价值的生物活性化合物.
这些化合物的有效提取和配方仍然具有挑战性.

研究的目的:

开发和特征纳米大小的杂交体 (NSHs) 从杉针同质化.
评估大规模NSH生产的可行性.
研究NSHs的组成和特性.

主要方法:

通过结合莱西丁,甘和杉杉针同质超剂来合成NSH.
鉴定包括光显微镜,冷传输电子显微镜,流动细胞计,动态光散射,UV-Vis光谱,干扰光显微镜和LC-MS.
分析了粒子的大小,度和组成.

主要成果:

NSHs具有双层膜和类似流体的内部,其中大多数是纳米大小 (140-180nm水力动力半径).
颗粒度达到了10^13-10^14/mL,明显超过了自然的细胞外囊泡产量.
在NSHs中确定了杉特定的脂质和蛋白质.

结论:

NSHs代表了一种新的,丰富的生物活性化合物的来源,来自松树针.
简单,低成本和高效的制备方法促进了大规模生产.
作为植物化学品的可持续和有效的输送系统,NSH显示出有希望.

关键词:

药物输送是药物输送的过程.细胞外颗粒细胞外颗粒杂交生体是杂交生体.脂质体是一种脂质体.纳米纤维的纳米纤维.小小的细胞颗粒.

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