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Updated: Jul 2, 2025

Using Touch-evoked Response and Locomotion Assays to Assess Muscle Performance and Function in Zebrafish
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M1肌性受体的混合体调节剂 提高乙胆的有效性,降低斑马鱼的运动活动和转向行为

Corey J Widman1, Sestina Ventresca1, Jillian Dietrich1

  • 1University of Toledo.

Research square
|February 27, 2024
PubMed
概括

新的阳性全调节剂 (PAM) 增强肌酸乙胆受体 (mAChR) 疗效,有望治疗像自闭症谱系障碍 (ASD) 这样的神经系统疾病,并降低毒性.

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Cholinergic agonists or cholinomimetics mimic the action of acetylcholine to stimulate the parasympathetic nervous system. They are categorized into direct-acting and indirect-acting agents. The direct-acting cholinergic drugs induce the parasympathetic response by directly binding to the muscarinic or nicotine receptors. In comparison, the indirect-acting cholinergic drugs prevent acetylcholine hydrolysis, indirectly contributing to the extended parasympathetic response.
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The pharmacological actions of acetylcholine are elicited via its binding to two families of cholinergic receptors or cholinoceptors, namely, muscarinic and nicotinic receptors. Muscarinic receptors are G protein-coupled receptors and have five subtypes, M1–M5. All mAChR subtypes are activated by acetylcholine and blocked by the antagonist, atropine. 
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Direct-acting cholinergic agonists, such as synthetic choline esters and naturally occurring alkaloids, exert their effects by enhancing the actions of acetylcholine and stimulating the parasympathetic nervous system. Synthetic choline esters share structural similarities with acetylcholine. For example, they have a positively charged quaternary ammonium or onium group, contributing to their hydrophilic characteristics. As a result, they are poorly absorbed in the body through oral...
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