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增加LOXL2表达与肺状细胞癌的预后不佳有关

Lei Cao¹, Jian Zhong¹, Zicheng Liu¹

¹Department of Thoracic Surgery, Nanjing Chest Hospital, Affiliated Nanjing Brain Hospital Nanjing Medical University, Nanjing, China.

Journal of thoracic disease

|February 27, 2024

概括

类似酸氧化酶2 (LOXL2) 在肺状细胞癌 (LUSC) 中被上调,并与患者的存活率差相关. 在LUSC.中,LOXL2可以作为预后生物标志物和治疗标.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
癌症研究癌症研究

背景情况:

类似于lysyl氧化酶 (LOXL) 的家族与癌症的发展有关.
在肺癌中LOXL家族成员的预后意义仍然不清楚.
这项研究调查了肺状细胞癌 (LUSC) 中LOXLs的表达和预后价值.

研究的目的:

在LUSC.中确定LOXL家族成员的表达模式.
在LUSC患者中评估LOXL家族成员的预后价值.
评估LUSC中LOXLs的诊断潜力.

主要方法:

使用统计分析 (Wilcoxon测试,逻辑回归,Kaplan-Meier,Cox回归) 来评估LOXL表达及其与临床特征和存活率的相关性.
用于诊断和预后功率评估,计算了接收器操作特征 (ROC) 曲线和曲线下的面积 (AUC).
进行了体外试验 (CCK-8,伤口愈合,Transwell) 来研究LOXL2在LUSC细胞中的功能作用.

主要成果:

在LUSC组织中,LOXL1和LOXL2表达显著上调.
LOXL1和LOXL2显示了对LUSC的高诊断能力.
较高的LOXL2表达与较差的整体存活率 (OS) 和无进展存活率 (PFS) 相相关,是不良结果的独立预后因素. 抑制LOXL2可以减少LUSC细胞的增殖,迁移和入侵.

结论:

增加LOXL2表达与LUSC患者的不良生存率有关.
LOXL2具有作为LUSC.预后生物标志物的潜力.
在LUSC治疗中,LOXL2可能是一个有前途的治疗标.

关键词:

这是一种类似于lysyl oxidase的蛋白质.生物标志物生物标志物肺状细胞癌 (LUSC) 是一种类似于lysyl氧化酶的蛋白2 (LOXL2)

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