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在中国人口中建立和应用FEF₅₀和FEF₇₅的参考方程

Zhufeng Wang¹, Yi Gao¹, Wenhua Jian¹

¹National Clinical Research Center for Respiratory Disease, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Journal of thoracic disease

|February 27, 2024

概括

为中国人口开发了强迫呼吸流的新参考方程式,其强迫活力容量的50%和75% (FEF50和FEF75). 这些方程可以更好地检测喘和COPD患者的小呼吸道功能障碍.

科学领域:

肺部医学肺部医学
呼吸系统生理学呼吸系统生理学
临床诊断临床诊断临床诊断

背景情况:

在中国人口中缺乏FEF50和FEF75的既定参考方程.
年龄特定方程在呼吸系统健康评估中的临床应用的重要性.

研究的目的:

使用LMS方法为中国人口建立FEF50和FEF75的新参考方程.
评估这些新方程式的临床适用性和诊断准确性.

主要方法:

利用了来自7115名健康的中国人 (4-80岁) 的肺功能数据.
在方程构造中使用了lambda-mu-sigma (LMS) 方法.
将新的方程与现有的欧洲方程进行比较,并分析了喘和COPD患者的支气管扩展剂反应.

主要成果:

开发了FEF50和FEF75的新参考方程,与1993年ECSC方程相比,显示出更高的精度 (较低的Z值和PE).
在使用新方程式的喘 (95.7%) 和慢性肺炎 (99.9%) 患者中确定了小呼吸道功能障碍 (SAD) 的高比例.
在喘 (48%±47%) 和COPD (20%±30%) 患者中,经过支气管扩张后观察到小气道指数的显著改善.

结论:

新建立的FEF50和FEF75的参考方程被推用于中国的临床应用.
需要进一步的研究来验证这些方程对于慢性呼吸道疾病的诊断效用.

关键词:

引用方程式的引用方程式兰巴-穆-西格玛 (LMS) 的使用小气道索引是小气道索引.

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