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陶积累及其在阿尔茨海默氏病频谱中的空间进展
Frédéric St-Onge1,2, Marianne Chapleau3, John C S Breitner2,4
1Integrated Program in Neuroscience, Faculty of Medicine, McGill University, Montreal, QC H3A 2B4, Canada.
Brain communications
|February 27, 2024
概括
阿尔茨海默病的 tau 积累在个体之间有很大差异,即使是在已建立的 Braak 阶段内. 这种tau病理在早期疾病阶段传播最快,在整个大脑中不同影响认知.
科学领域:
- 神经科学是一个神经科学.
- 神经病理学神经病理学
- 医疗成像医学成像
背景情况:
- 阿尔茨海默氏病 (AD) 的积传统上与布拉克分期有关.
- 新兴的PET证据表明,在AD中存在异质的沉积模式.
- 传播的个体变异性使得了解疾病进展变得复杂.
研究的目的:
- 调查tau病理在临床前和临床间歇性AD的空间分布.
- 评估陶积累模式与认知衰退之间的关联.
- 为了比较一个新的空间范围指数与传统的tau负载代理.
主要方法:
- 分析了阿尔茨海默病神经成像计划的832名参与者的纵向tau-PET数据.
- 在70个大脑区域定义了异常的沉积值 (Desikan atlas).
- 开发了一个空间范围指数,并将其与对认知关联感兴趣的时间元区域进行了比较.
主要成果:
- 超过80%的粉样β阳性参与者遵循布拉克分期,但在tau沉积中观察到显著的区域异质性 (重叠<50%).
- 陶氏病理在没有认知障碍和轻度认知障碍 (MCI) 组 (1.2区域/年) 的进展速度快于AD痴呆症 (<1区域/年).
- 空间范围指数比时间代理更好地识别了与记忆 (认知不受损害) 和执行功能 (MCI/AD痴呆症) 的关联.
结论:
- 尽管广泛遵循布拉克阶段,但在AD的所有临床阶段都存在tau沉积的显著个体异质性.
- 病理的空间传播在临床前和MCI阶段最快.
- 评估的空间分布可以更全面地了解阿尔茨海默病理和认知障碍.
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