对于骨质疏松症治疗的通用阿伦德罗纳酸的有效性和安全性
Atthakorn Jarusriwanna1, Saran Malisorn1, Sirikarn Tananoo1
1Department of Orthopaedics, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand.
Orthopedic research and reviews
|February 27, 2024
概括
通用阿伦德罗纳特通过增加关键部位的骨矿物质密度来有效治疗骨质疏松症. 这种双酸盐药物在患有骨质疏松症的患者中表现出不良副作用的发生率很低.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 老年病的医生 老年病的医生
背景情况:
- 骨质疏松症显著增加骨折风险.
- 双酸盐增强骨强度,减少骨折的发生率.
- 通用药物为骨质疏松症管理提供了具有成本效益的替代品.
研究的目的:
- 在骨质疏松症患者中评估通用阿伦德罗纳酸的疗效.
- 评估与通用阿伦德罗纳特治疗相关的安全性和不良事件.
- 为了确定通用阿伦德罗纳酸对骨矿物质密度 (BMD) 的影响.
主要方法:
- 对120名骨质疏松症患者进行了回顾性审查,这些患者接受了通用阿伦德罗纳特 (每周70毫克) 治疗一年多.
- 骨矿物质密度 (BMD) 变化测量在腰椎,大腿部和全部,使用双能X射线吸收计 (DXA).
- 关于导致药物停用的不良事件的记录.
主要成果:
- 一年后,在腰椎 (5.6%),大腿部 (2.3%) 和整个部 (2.1%) 观察到显著的BMD增加 (分别p<0.001,p=0.023,p=0.003).
- 超过85%的患者表现出增加或稳定的BMD.
- 副作用很少发生,只有三名患者停止治疗 (两名为消化不良,一名为肌痛痛).
结论:
- 通用阿伦德罗纳酸是一种有效的骨质疏松症抗吸收剂.
- 这种治疗具有较低的副作用发生率.
- 通用阿伦德罗纳特代表了骨质疏松症管理的可行和安全的选择.
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