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大肠癌中的肠道微生物群和表观遗传学:对致癌和治疗干预的含义

Monu Pandey^1,2, Jayanta Bhattacharyya^1,2

¹Centre for Biomedical Engineering, Indian Institute of Technology, Delhi, 110016, India.

|February 27, 2024

概括

肠道微生物群通过诸如DNA甲基化之类的表观遗传变化影响结肠直肠癌 (CRC). 了解这些肠道微生物组-CRC表观遗传联系可以帮助早期检测和治疗策略.

科学领域:

在瘤学瘤学.
微生物学微生物学
表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.

背景情况:

结肠直肠癌 (CRC) 是一个主要的全球健康问题,通常是由肠道细胞的遗传和表观遗传变化引起的.
人们越来越认识到肠道微生物群对调节宿主生理学的作用.
失生症,或改变肠道微生物群的组成,与癌症的发展有关.

研究的目的:

审查最近关于肠道微生物群和结直肠癌 (CRC) 之间的关联的发现.
提供关于连接肠道微生物群和CRC的表观遗传机制的见解.
突出CRC早期检测和治疗的潜在应用.

主要方法:

对最近的科学发现进行了全面的文献审查.
专注于表观遗传修饰,包括基因素修饰,ncRNAs和DNA甲基化.
对研究肠道微生物群组成及其在CRC病变发生中的作用的研究进行分析.

主要成果:

有证据表明,肠道微生物群的改变通过表观遗传修饰启动了致癌.
特定的表观遗传机制,如DNA甲基化和ncRNAs受肠道微生物的影响.
肠道微生物群和宿主表观遗传学的相互作用对CRC发育至关重要.

结论:

肠道微生物群通过表观遗传调节在CRC发育中发挥着重要作用.
对肠道微生物群-CRC轴的表观遗传洞察力为新的治疗策略提供了潜力.
对这些关联的进一步研究可以促进早期CRC检测和治疗.

关键词:

通过DNA甲基化.结肠直肠癌是什么意思表观遗传学是指表观遗传学.我们的肠道微生物群.基斯顿基因基因基因基因基因基因基因基因基因基因基因基因基因这是一个ncRNARNA.

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