和其他化学元素在亲肠道营养成分和全合一添加剂中的成分
Katja A Schönenberger1, Christoph Saxer2, Peter J Neyer2
1Institute of Laboratory Medicine, Cantonal Hospital Aarau, Tellstrasse 25, 5001 Aarau, Switzerland; Division of Clinical Pharmacy and Epidemiology, Department of Pharmaceutical Sciences, University of Basel, Spitalstrasse 26, 4056 Basel, Switzerland; Department of Diabetes, Endocrinology, Nutritional Medicine and Metabolism (UDEM), Inselspital, Bern University Hospital, University of Bern, Freiburgstrasse 15, 3010 Bern, Switzerland.
某些亲肠道营养 (PN) 产品含有高 (Al) 含量,超过安全限值. PN处理过程和输液套件不会增加显著的Al污染.
科学领域:
- 临床化学 临床化学
- 营养科学 营养科学
- 分析化学 分析化学
背景情况:
- 亲肠道营养 (PN) 管理可能会导致显著的 (Al) 暴露.
- 在PN中高的Al水平可能对患者构成毒理风险.
研究的目的:
- 量化Al和其他元素度在全合一 (AIO) PN添加剂中.
- 为了评估PN混合和输液组使用的Al污染.
主要方法:
- 诱导合等离子体质谱法 (ICP-MS) 用于元素定量.
- 样品在混合后48小时内进行分析.
- 测量Al度与计算值进行了比较.
主要成果:
- 在AIO PN添加剂中的基线Al度差异很大,有些超过25μg/L的极限.
- 在48小时内,Al水平略有下降.
- 从混合或输液套件中没有发现显著的Al污染.
结论:
- 某些商业PN添加剂含有过量的Al,需要监管监督.
- PN处理和输注材料不会导致Al污染.
- 计算的Al度准确地反映了室内的含量.
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