在血液透析患者中计算的血体积状态
Qiankun Zhang1, Hang Fang1,2, Lie Jin1
1Division of Nephrology, the Fifth Affiliated Hospital of Wenzhou Medical University, Lishui Central Hospital, Lishui Hospital of Zhejiang University, Lishui, China.
Renal failure
|February 27, 2024
概括
计算的血体积 (PV) 有效地预测血液透析 (HD) 患者的体积过载. 在HD患者中,较高的时间平均PV状态 (PVS) 与死亡风险增加有关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心血管生理学心血管生理学
- 生物医学工程 生物医学工程
背景情况:
- 血红素和体重的血体积 (PV) 估计对心血管疾病管理有影响.
- 该研究评估了计算PV在预测体积过载方面的准确性及其在血液透析 (HD) 患者的预后价值.
研究的目的:
- 评估计算血体积 (PV) 的有效性,以预测血液透析 (HD) 患者的体积过载.
- 为了确定计算PV状态 (PVS) 对HD患者全因死亡率的预后效用.
主要方法:
- 54名疾病患者接受了生物电阻分析 (BIA),以测量总体水 (TBW),细胞内水 (ICW),细胞外水 (ECW) 和过 (OH).
- 计算了实际的PV (aPV) 和相对的PV状态 (PVS). 一个由164名HD患者组成的回顾性队列被用来将PVS与死亡结果联系起来.
主要成果:
- 实际PV (aPV) 与细胞外水 (ECW) (r=0.83) 和预测体积过载 (AUC=0.770) 有着很强的相关性.
- 较高的PVS值和时间平均PVS值显著与HD患者全因死亡率的增加有关.
- 时间平均PVS超过8.72%表明所有原因死亡风险增加了2.48倍 (HR=2.48,p=0.0023).
结论:
- 实际血体积 (aPV) 与通过BIA测量的细胞外水 (ECW) 有很强的相关性.
- 在血液透析患者中,时间平均血体积状态 (PVS) 的升高是所有原因死亡率较高的重要预测因素.
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