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使用OxyChip进行皮下氧度测试的手持电子自旋共振扫描仪

Nir Almog¹, Oleg Zgadzai¹, Periannan Kuppusamy²

¹Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa, Israel.

Magnetic resonance in medicine

|February 27, 2024

概括

一种新的紧型电子旋转共振 (ESR) 扫描仪,可以非侵入性地测量皮下氧气部分压力 (pO2). 这项技术在伤口愈合和临床诊断方面表现有前途.

科学领域:

生物医学工程生物医学工程
医学物理医学物理
分析化学分析化学

背景情况:

电子自旋共振 (ESR) 是一种在生物环境中测量氧的部分压力 (pO2) 的技术.
传统的ESR方法使用大型磁铁,限制了它们的临床应用.
开发了一种新的紧型ESR扫描仪,用于通过皮肤测量pO2.

研究的目的:

为了扩大一个紧的ESR扫描仪在地下 (皮肤下) pO2测量的能力.
为了验证扫描仪的性能,使用人工组织仿真 (ATE) 幻影.
评估ESR测量中局部静态磁场操作的潜力.

主要方法:

一台新的紧型ESR扫描仪被设计用于最深2毫米的皮下测量.
扫描仪利用来自嵌入的1毫米氧气感应性偏磁性植入物 (OxyChip) 的脉冲ESR信号.
关键组件包括静态磁场源和紧的微波共振器.

主要成果:

扫描仪准确地测量了pO2水平 (0,7.6,30,160 mmHg) 从一个OxyChip嵌入1.5毫米深的ATE幻影中.
观察到1/T2和pO2之间的线性关系.
相对读数准确率约为10%.

结论:

紧型ESR扫描仪成功地向外部报告了皮下pO2数据.
这项技术可用于皮下pO2监测的临床前和临床应用.
该扫描仪有可能与人工皮肤移植集成,用于伤口愈合,结合治疗和诊断.

关键词:

在OxyChip上使用OxyChip.一个紧的磁铁磁铁.氧度测量方法氧度测量方法脉冲式ESR是指一个脉冲式的ESR.组织的pO2

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