亚洲国家潜在结核病感染的流行:系统性审查和元分析
Abhigan B Shrestha1, Imran S Siam2, Jarin Tasnim2
1Department of Internal Medicine, M Abdur Rahim Medical College, Dinajpur, Bangladesh.
Immunity, inflammation and disease
|February 27, 2024
概括
亚洲近四分之一的人口患有潜伏性结核病感染 (LTBI). 这一系统性审查强调了诊断方面的挑战,并建议大规模查计划,以有效控制亚洲的结核病.
科学领域:
- 公共卫生 公共卫生
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 结核病 (TB) 构成一个重大的全球卫生挑战,亚洲国家负担很高.
- 亚洲人口的很大一部分患有潜伏性结核病感染 (LTBI).
研究的目的:
- 系统地审查和分析亚洲国家的LTBI的流行情况.
- 通过使用不同的诊断方法,在亚洲各个次区域评估LTBI的患病率.
主要方法:
- 在PubMed,Embase和ScienceDirect (2005-2023) 的系统文献搜索.
- 使用随机效应模型进行元分析,将来自TST和IGRA的流行数据汇集在一起.
- 基于时间段,诊断测试 (QFT,TSPOT) 和地理区域的子组分析.
主要成果:
- 亚洲的整体LTBI患病率为21% (IGRA) 和36% (TST).
- 根据IGRA,在2011-2016年 (20%) 和2017-2023年 (21%) 之间,患病率保持一致.
- 观察到区域差异,南部/东南部地区的流行率较高,西部地区的流行率较低.
结论:
- 亚洲人口中有很大一部分生活在LTBI中,这给诊断带来了挑战.
- 建议进行大规模查计划,提高公众意识和提供治疗.
- 干预策略必须考虑负担能力,可用性和成本效益.
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