大脑N - 乙-氨基酸与艾滋病毒病毒被抑制的老年人的认知功能有关
Robyn L Wiseman1,2,3, Kristin L Bigos1,3,4, Raha M Dastgheyb5
1Department of Pharmacology and Molecular Sciences.
AIDS (London, England)
|February 27, 2024
概括
大脑中的N-乙-酸甘氨酸 (NAAG) 水平与HIV病毒抑制患者 (VS-PWH) 的认知功能相关. 额头白质和基底质中较高的NAAG与更好的注意力和语言流性有关,这表明NAAG是潜在的生物标志物.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 艾滋病毒研究 艾滋病毒研究
背景情况:
- 认知障碍在艾滋病病毒抑制患者 (VS-PWH) 中很常见,特别影响更高阶的认知领域.
- N-乙-阿斯巴提尔谷氨酸 (NAAG),一种内源性甲基胺3受体的激动剂,调节涉及认知的皮质电路.
- 谷氨酸碳酸酶II (GCPII) 降解NAAG,并与衰老和疾病有关;其抑制可增强大脑NAAG,并增强动物模型中的认知能力.
研究的目的:
- 通过磁共振光谱法 (MRS) 测量的大脑NAAG水平与VS-PWH中的认知功能之间的关联.
- 探索NAAG作为这种人群中认知缺陷的潜在生物标志物,鉴于其在以前的MRS研究中未被检查的作用.
主要方法:
- 对40名老年VS-PWH (年龄大于50岁) 的7特斯拉MRS数据进行了回顾性分析.
- 量化前额白质 (FWM),左海马体和左基底质中的区域NAAG水平.
- 对NAAG水平和特定领域的认知表现之间的相关性分析,调整为混.
主要成果:
- 在FWM中NAAG升高与注意力和工作记忆的改善有关.
- 在左下基底质中较高的NAAG与增强的口语流性相关.
- 观察到海马NAAG与执行功能之间的积极关联趋势,但在混杂校正后没有达到统计学意义.
结论:
- 大脑NAAG水平可能成为VS-PWH认知功能的有价值生物标志物.
- 通过药理学调制准大脑NAAG是解决VS-PWH认知缺陷的潜在治疗策略.
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