患有偏头痛的ERENUMAB治疗患者的血压升高:回顾现实世界的经验
Nikita Chhabra1, Carolyn Mead-Harvey2, Christopher A Dodoo2
1Department of Neurology, Mayo Clinic, Scottsdale, Arizona, USA.
Headache
|February 27, 2024
概括
作为偏头痛预防剂的埃伦纽马布与23.3%的患者的血压恶化有关. 这凸显了接受erenumab治疗偏头痛的患者需要定期监测血压的必要性.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 埃雷努马布是一种CGRP受体对抗剂,用于偏头痛预防.
- 虽然临床前和临床试验没有显示高血压风险,但营销后的数据和FDA标签表明存在潜在的关联.
- 素基因相关 (CGRP) 在调节血管度方面发挥作用.
研究的目的:
- 评估在开始使用erenumab后偏头痛患者血压升高 (BP) 的发生率.
- 调查埃伦乌马布使用与血压恶化 (包括高血压) 之间的关系.
主要方法:
- 进行了一项观察性回顾性队列研究.
- 使用美国心脏协会分期,比较了erenumab启动前和后的血压 (BP).
- 还记录了严重的血管不良事件.
主要成果:
- 在335名患者中,23.3%的血压恶化;3.9%的血压改善.
- 血压恶化与心房 (OR 4.9,p=0.035) 有关,但与基线高血压,性别,BMI或年龄无关.
- 一名患者经历了高血压紧急情况与非ST升高心肌梗塞.
结论:
- 相当一部分患者 (23.3%) 服用埃伦鲁马布可能会经历血压恶化.
- 建议在开始治疗erenumab的患者监测血压.
- 进一步的研究可能会澄清 erenumab 相关的血压变化的机制和临床意义.
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