奎尔塞丁通过ERK/STAT3通路调节微质M1/M2极化,并通过ERK/STAT3通路缓解视网膜炎症
Yue Zou1,2, Junliang Jiang3, Yunqin Li2
1Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, China NHC Key Laboratory of Myopia (Fudan University) Key Laboratory of Myopia Chinese Academy of Medical Sciences, Fudan University, 83 Fenyang Road, Xuhui District, Shanghai, 200031, China.
Inflammation
|February 27, 2024
概括
奎尔 (Qu) 通过将微质转移到保护M2表型来减少视网膜炎症. 这种饮食化合物保护光受体,并在视网膜疾病模型中保持视力.
科学领域:
- 眼科医生 眼科 眼科
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- 由微质激活驱动的视网膜炎症是退行性眼睛疾病的核心,如与年龄相关的黄斑退行 (AMD).
- 素 (Qu),一种饮食中的黄类化合物,显示出抗神经炎症的潜力,但它对视网膜炎症的特定影响需要澄清.
研究的目的:
- 在小鼠中研究奎尔对脂聚糖 (LPS) 诱导的视网膜炎症的治疗作用.
- 阐明瑞对微质激活和视网膜保护的作用的潜在机制.
主要方法:
- 在使用LPS的C57BL/6J小鼠中诱导视网膜炎症.
- 进行素预治疗,以评估其对微质表型,炎症标志物和血液视网膜屏障 (BRB) 完整性的影响.
- 在体外研究中,研究了奎瑞对微质激活,增殖,迁移以及ERK/STAT3信号通路的影响.
主要成果:
- 奎尔素预处理将微质从促炎M1转移到抗炎M2表型.
- 奎尔素显著减轻了视网膜炎症,并保持了BRB的完整性.
- 在体外,Quercetin通过ERK/STAT3通路抑制了微质激活,增殖和迁移,从而导致光受体的保存.
结论:
- 奎尔在减轻视网膜炎症和保护视觉功能方面显示出显著的潜力.
- 通过Quercetin针对微质激活提供了一个有前途的治疗策略,用于视网膜退行性疾病.
更多相关视频
06:24Generation of Human Microglia to Combine Them with Retinal Organoids for Improved Disease Modeling
Published on: July 26, 2024
1.2K
08:15Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
Published on: June 6, 2025
52
相关概念视频
Receptor Downregulation in MVBs
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR activation may...
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR activation may...
The JAK-STAT Signaling Pathway
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
