便失禁与肠-大脑相互作用的并发障碍:一个更糟糕的结果
Sarah G Li1,2,3, Yoav Mazor4,5, Calvin Joomann Park1,2
1The University of Sydney, Sydney, New South Wales, Australia.
United European gastroenterology journal
|February 27, 2024
概括
患有便失禁的患者往往有额外的肠脑相互作用障碍 (DGBI). 更多的DGBI与更糟糕的症状,焦虑,抑郁和生活质量相关,强调需要全面查.
科学领域:
- 胃肠病学和神经胃肠病学
- 精神病学和心理学 精神病学和心理学
- 公共卫生 公共卫生
背景情况:
- 便失禁 (FI) 是一种普遍的,使人虚弱的疾病,影响生活质量和医疗费用.
- 肠-大脑相互作用 (DGBI) 的同时出现的障碍在FI患者中很常见.
- 多个DGBI对FI患者结果的影响需要进一步调查.
研究的目的:
- 评估额外的DGBI对FI患者症状严重性的影响.
- 评估FI中DGBI和心理困扰 (焦虑,抑郁) 之间的关联.
- 确定合并性DGBI对FI患者生活质量的影响.
主要方法:
- 追溯队列研究的设计.
- 从2007年至2020年,包括从2007年至2020年为FI转诊到第三级神经胃肠病学中心的患者.
- 从验证的问卷 (罗马III,FI严重性指数,HADS,SF-36) 和直肠生理学测试中分析数据,根据DGBI计数对患者进行分类.
主要成果:
- 患有FI的患者平均有2.2个额外的DGBI,主要影响肠道和直肠区域.
- 增加的DGBI计数与更高的FI症状严重程度 (p<0.001),焦虑 (p=0.002) 和抑郁 (p=0.003) 有显著的相关性.
- 心理健康 (p=0.037) 和社会影响 (p<0.001) 领域中观察到生活质量较差,有更多的DGBIs;没有发现与直肠生理学的关联.
结论:
- 在FI患者中,DGBI的较高负担与症状恶化,心理困扰和生活质量下降有关.
- 直肠生理学似乎与同时发生的DGBI的数量无关.
- 针对并发性DGBI的积极查对于综合性便失禁的综合管理至关重要.
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