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Updated: Jul 2, 2025

Assessment of Immunologically Relevant Dynamic Tertiary Structural Features of the HIV-1 V3 Loop Crown R2 Sequence by ab initio Folding
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类似于VRC13的bNAb反应与HIV-1包裹中的复杂逃生途径有关

Vinita R Joshi1,2,3, Daniel T Claiborne1, Melissa L Pack1

  • 1Ragon Institute of Mass General, MIT and Harvard, Cambridge, Massachusetts, USA.

Journal of virology
|February 27, 2024
PubMed
概括

了解HIV-1的进化是设计产生广泛中和抗体 (bNAbs) 的免疫原体的关键. 这项研究揭示了针对VRC13类抗体的复杂病毒逃生途径,确定了未来免疫原体设计的关键突变.

关键词:
这是一个CD4bs.艾滋病病毒 艾滋病病毒 艾滋病病毒在VRC13中使用VRC13.bNAbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbcbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbcbbbbbbbbbbcbbbbbbbbbbbbcbbbbbbbbbbbbcbbbbbbbbbbbbbbcbbbbbbbbbbcbbbbbbbbbbbbbbbbbbbcbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbcbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbbb逃跑 逃跑 逃跑 逃跑 逃跑 逃跑进化 演化 演化 演化 演化 演化 演化 演化

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