从两动物Anurans获得的专利抗菌的全面审查
Fabiola Almeida García1, Talia Frómeta Fuentes2, Isel Pascual Alonso2
1NPPNS, Department of Biomolecular Sciences, Faculty of Pharmaceutical Sciences of Ribeirão Preto, Department of Physics and Chemistry, University of São Paulo, Avenida do Café, s/no, 14040-903 Ribeirão Preto, Brazil.
Journal of natural products
|February 27, 2024
概括
安的皮肤分泌物产生各种抗微生物 (AMP),具有药物潜力. 专利分析显示,亚洲在AMP研究中处于领先地位,突出了生物多样性保护的必要性,以支持药物发现.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 生物多样性研究 生物多样性研究
背景情况:
- 来自anuran皮肤分泌物的抗菌 (AMP) 具有显著的结构多样性和生物活性.
- 自20世纪80年代以来,对这些的研究一直在进行,揭示了它们的治疗潜力.
研究的目的:
- 为了探索anuran衍生AMP的药物开发潜力.
- 分析与这些相关的授予专利,氨基酸修改和分类学更新.
主要方法:
- 进行了关于anuran的授予专利的全面搜索.
- 分析专利数据,重点关注地理分布,声称活动和序列修改.
- 审查了影响anuran AMP命名的最近的分类学更新.
主要成果:
- 确定了188项与酸相关的专利,其中亚洲 (65.4%) 和北美 (15.4%) 主导专利申请.
- 在118项专利中声称抗菌活性.
- 对自然序列的修改,包括侧链改变和N-/C-终端变化,在专利衍生品中很常见.
结论:
- 由阿努兰衍生的AMP在药物开发方面具有相当大的生物医学潜力.
- 在AMP的描述和其进展到实际药物开发之间存在很大的差距.
- 生物多样性保护对于未来的生物医学发现至关重要.
相关概念视频
Antimicrobial Proteins
990
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
990
Surface Membrane Barriers
1.1K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.1K


