氨基酸配方诱导了小鼠的微生物群失调和类似抑郁的行为
Ji Hu1, Kaixin He1, Yifei Yang2
1Key Laboratory of Immune Response and Immunotherapy, Center for Advanced Interdisciplinary Science and Biomedicine of IHM, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China; The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, China.
Cell reports
|February 27, 2024
概括
氨基酸配方 (AAF) 可能会对婴儿健康产生负面影响. 这项研究发现,AAF养的小鼠发展了肠道失调,增加了神经元活动和抑郁行为,这表明潜在的长期风险.
科学领域:
- 微生物学 微生物学
- 神经科学是一个神经科学.
- 儿童营养学 儿童营养学
背景情况:
- 氨基酸配方 (AAF) 是牛奶蛋白质过敏的婴儿的常见替代品.
- 消费AAF对健康的长期影响,特别是对肠道微生物群和神经发育的影响,尚不清楚.
研究的目的:
- 在新生儿小鼠模型中研究氨基酸饮食 (AAD) 对健康的长期影响.
- 探索肠道微生物群在调解AAD对神经元活动和行为的影响中的作用.
主要方法:
- 新生儿小鼠被食AAD以模拟婴儿的AAF消耗.
- 研究人员评估了肠道微生物群的组成,肠道和大脑中的神经元活动,胃肠道功能和类似抑郁的行为.
- 便微生物种移植 (FMT) 实验是使用AAD养小鼠和AAF养婴儿的微生物进行的.
主要成果:
- 用AAD养的小鼠表现出显著的肠道失调,肠道和大脑神经元活动增加,胃肠道运动障碍和类似抑郁的行为.
- 从AAD养小鼠或AAF养婴儿到接受小鼠的FMT诱导了神经元活性升高和抑郁行为恶化.
- 相反,从正常食小鼠或牛奶配方养的婴儿身上获得的FMT并没有产生这些不良影响.
结论:
- 该研究表明,长时间食用AAF可能会导致儿童的神经发育和心理健康不良结果.
- 肠道微生物群失调似乎在调解AAF的负面影响方面发挥着至关重要的作用.
- 研究结果强调需要谨慎使用AAF,并进一步研究其长期健康影响.
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