元素铁可以保护肠道微生物群免受氧气诱导的生物失调
Ievgeniia Ostrov1, Yongjia Gong2, Joshua B Zuk1
1Department of Plant Biology, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, New Jersey, United States of America.
PloS one
|February 27, 2024
概括
元素铁作为抗氧化剂,逆转氧气诱导的肠道失调,并保护微生物多样性. 这一发现表明铁是铁.
科学领域:
- 微生物组研究的研究.
- 肠道健康 肠道健康
- 氧化应激是一种氧化应激.
背景情况:
- 与氧气和活性氧物种 (ROS) 相关的肠道失生症可能导致炎症,代谢综合征和与肠道相关的疾病.
- 氧化压力与破坏肠道微生物群的平衡和功能有关.
研究的目的:
- 研究元素铁作为抗氧化剂的潜力,以抵消氧气诱导的肠道失调.
- 为了确定元素铁是否可以恢复肠道微生物群的多样性和在氧化应激下的功能.
主要方法:
- 用元素铁和/或氧气发酵来自健康捐赠者的便样本.
- 16S rRNA基因测序以分析肠道微生物群的组成和多样性 (香农指数).
- 对短链脂肪酸 (SCFA) 生产的分析.
主要成果:
- 元素铁逆转了由氧引起的肠道微生物多样性的破坏 (香农指数).
- 缺乏酶性抗氧化系统的细菌在铁处理后增加.
- 氧抑制了SCFA的产生,这种效应被元素铁部分逆转. 特定的细菌协会对氧气和铁的反应有所不同.
结论:
- 元素铁具有抗氧化特性,有效地保护肠道微生物群免受氧化应激.
- 铁可以调节肠道内的氧/ROS平衡,为失生症提供潜在的治疗策略.
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