24小时尿液中的预测了初级甲状腺障碍症手术后减少骨折发生率和改善骨矿物质密度
Martin Nilsson1,2, Kristina E Åkesson3,4, Mark Thier1,2
1Department of Clinical Sciences, Lund University, 221 84 Lund, Sweden.
The Journal of clinical endocrinology and metabolism
|February 27, 2024
概括
在手术前24小时尿液中水平预测骨折风险降低,并在治疗原发性甲状腺功能障碍症 (pHPT) 的甲状腺膜切除术后改善骨密度. 这一发现有助于管理pHPT患者的骨健康.
科学领域:
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
- 外科手术的结果
背景情况:
- 当代的原发性甲状腺功能障碍症 (pHPT) 呈现出较轻微的疾病,使手术结果的预测因素变得不那么清楚.
- 在pHPT中缺乏影响术后骨折发生率和骨矿物密度 (BMD) 的确定的临床和生化因素.
研究的目的:
- 为了确定骨折发生率的术前和术后预测因素.
- 为了调查骨矿物质密度 (BMD) 变化的预测因子,pHPT的副甲状腺切除术后.
主要方法:
- 预期的手术队列研究与匹配的人口对照.
- 与国家卫生登记处 (瑞典国家患者登记处,处方药登记处,死亡原因登记处) 的数据链接.
- 包括709名经过副甲状腺切除术的pHPT患者和2112名对照患者;在1年的随访中评估骨折发生率和骨质量变化.
主要成果:
- 患有pHPT的患者在手术前表现出较高的骨折发病率,手术后正常化.
- 手术后骨折发生率与手术前24小时尿液水平相反相关.
- 血清/尿液,副甲状腺激素,骨和腺瘤重量预测了手术后的BMD恢复.
结论:
- 手术前的24小时尿液是减少pHPT手术后骨折风险的关键生化预测因子.
- 24小时尿中的也预测了pHPT的副甲状腺切除术后骨矿物密度恢复的改善.
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